Selected Studies Using Actimetrics Products

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Naoki Matsuo, Leon Reijmers, Mark Mayford (2008) Spine-Type Specific Recruitment of Newly Synthesized AMPA Receptors with Learning. Science 319: 1104-1107.

Leon G. Reijmers, Brian L. Perkins, Naoki Matsuo, Mark Mayford (2007) Localization of a Stable Neural Correlate of Associative Memory Science 317:1230-1233.

T.J. Kotti, D.M.O. Ramirez, B.E. Pfeiffer, K.M. Huber and D.W. Russell (2006) Brain cholesterol turnover required for geranylgeraniol production and learning in mice. PNAS 103:3869-3847.

M.D. Saxe, F. Battaglia, J.-W. Wang, G. Malleret, D.J. David, J.E. Monckton, A.D.R. Garcia, M.V. Sofroniew, E.R. Kandel, Luca Santarelli, R. Hen and M.R. Drew (2006) Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. PNAS 103:17501-17506.

S. Shalin, C. Hernandez, M. Dougherty, D. Morrison, J. Sweatt (2006) Kinase Suppressor of Ras1 Compartmentalizes Hippocampal Signal Transduction and Subserves Synaptic Plasticity and Memory Formation. Neuron, 50:765-779.

J.M. Long, P. LaPorte, S. Merscher, B. Funke, B. Saint-Jore, A. Puech, R. Kucherlapati, B.E. Morrow, A.I. Skoultchi and A. Wynshaw-Boris (2006) Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome. Neurogenetics, 7:247-257.

B.C. McKinney and G.G. Murphy (2006) The L-Type voltage-gated calcium channel Cav1.3 mediates consolidation, but not extinction, of contextually conditioned fear in mice. Learning and Memory, 13:584-589.

C.A. Saura, G. Chen, S. Malkani, S.-Y. Choi, R.H. Takahashi, D. Zhang, G.K. Gouras, A. Kirkwood, R.G.M. Morris and J. Shen (2006) Conditional Inactivation of Presenilin 1 Prevents Amyloid Accumulation and Temporarily Rescues Contextual and Spatial Working Memory Impairments in Amyloid Precursor Protein Transgenic Mice. Journal of Neuroscience, 25:6755– 6764.

L.G. Reijmers, J.K. Coats, M.T. Pletcher, T. Wiltshire, L.M. Tarantino and M. Mayford (2006) A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen. Learning and Memory, 13:143-149

Gleb P. Shumyatsky, Gaël Malleret, Ryong-Moon Shin, Shuichi Takizawa, Keith Tully, Evgeny Tsvetkov, Stanislav S. Zakharenko, Jamie Joseph, Svetlana Vronskaya, DeQi Yin, Ulrich K. Schubart, Eric R. Kandel, and Vadim Y. Bolshakov, (2005) stathmin, A gene enriched in the amygdala, controls both learned and innate fear Cell, 123:697-709.

Leon G. Reijmers, Jennifer K. Coats, Mathew T. Pletcher, Tim Wiltshire, Lisa M. Tarantino and Mark Mayford (2006) A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen. Learning and Memory 13:143-149.

Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher RJ 3rd, Kandel ER, Duff K, Kirkwood A, Shen J. (2005) Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42:23-36.

Michelle L. Gottsch, Hongkui Zeng, John G. Hohmann, David Weinshenker, Donald K Clifton, and Robert A. Steiner (2005) Phenotypic Analysis of Mice Deficient in the Type 2 Galanin Receptor (GALR2). Molecular and Cellular Biology 25:4804-4811

Carlos A. Saura, Guiquan Chen, Seema Malkani, Se-Young Choi, Reisuke H. Takahashi, Dawei Zhang, Gunnar K. Gouras, Alfredo Kirkwood, Richard G. M. Morris and Jie Shen (2005) Conditional Inactivation of Presenilin 1 Prevents Amyloid Accumulation and Temporarily Rescues Contextual and Spatial Working Memory Impairments in Amyloid Precursor Protein Transgenic Mice Journal of Neuroscience 25:6755-6764

X Zhou, J M Long, M A Geyer, E Masliah, J R Kelsoe, A Wynshaw-Boris, K R Chien (2005) Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization. Molecular Psychiatry 10:393-406.

MG Zhao, H Toyoda, SW Ko, HK Ding, LJ Wu, M Zhuo (2005) Deficits in Trace Fear Memory and Long-Term Potentiation in a Mouse Model for Fragile. Journal of Neuroscience 25: 7385-7392.

Kiyohiko Angata, Jeffrey M. Long, Olena Bukalo, Wenjau Lee, Alexander Dityatev, Anthony Wynshaw-Boris, Melitta Schachner, Minoru Fukuda|, and Jamey D. Marth (2004) Sialyltransferase ST8Sia-II Assembles a Subset of Polysialic Acid That Directs Hippocampal Axonal Targeting and Promotes Fear Behavior. J. Biol. Chem., 279:32603-32613.

Mesches, M.H., Gemma, C., Veng, L.M., Allgeier, C., Young, D.A., Browning, M.D. and Bickford, P.C. (2004) Sulindac improves memory and increases NMDA receptor subunits in aged Fischer 344 rats. Neurobiology of Aging 25:315-324.

Korzus, E., Rosenfeld, M.G. and Mayford, M (2004) CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation. Neuron 42:961-972.

Mark D. Lindner, Donald B. Hodges, Jr., John B. Hogan, Anitra F. Orie, Jason A. Corsa, Donna M. Barten, Craig Polson, Barbara J. Robertson, Valerie L. Guss, Kevin W. Gillman, John E. Starrett, Jr., and Valentin K. Gribkoff (2003) An Assessment of the Effects of Serotonin 6 (5-HT6) Receptor Antagonists in Rodent Models of Learning. Journal of Pharmacology And Experimental Therapeutics 307:682-691.

Miller S, Yasuda M, Coats JK, Jones Y, Martone ME, Mayford M. (2002) Disruption of dendritic translation of CaMKIIalpha impairs stabilization of synaptic plasticity and memory consolidation. Neuron 36:507-19.

WaterMaze

Richard E. Brown and Aimée A. Wong (2007) The influence of visual ability on learning and memory performance in 13 strains of mice. Learning and Memory 14:134-144.

Nohjin Kee1, Cátia M Teixeira, Afra H Wang, & Paul W Frankland (2007) Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nature Neuroscience 10:355 - 362.

Nohjin Kee1, Cátia M Teixeira, Afra H Wang, & Paul W Frankland (2007) Imaging activation of adult-generated granule cells in spatial memory. Nature Protocols 2:3033-3044

Cátia M. Teixeira, Stephen R. Pomedli, Hamid R. Maei, Nohjin Kee, and Paul W. Frankland (2006) Involvement of the Anterior Cingulate Cortex in the Expression of Remote Spatial Memory. Journal of Neuroscience 26:7555-7564.

Alvin V. Terry, Jr., Vinay Parikh, Debra A. Gearhart, Anilkumar Pillai, Elizabeth Hohnadel, Samantha Warner, Henry A. Nasrallah, and Sahebarao P. Mahadik (2006) Time-Dependent Effects of Haloperidol and Ziprasidone on Nerve Growth Factor, Cholinergic Neurons, and Spatial Learning in Rats. Journal of Pharmacology And Experimental Therapeutics 318:709-724.

Carlos A. Saura, Guiquan Chen, Seema Malkani, Se-Young Choi, Reisuke H. Takahashi, Dawei Zhang, Gunnar K. Gouras, Alfredo Kirkwood, Richard G. M. Morris and Jie Shen (2005) Conditional Inactivation of Presenilin 1 Prevents Amyloid Accumulation and Temporarily Rescues Contextual and Spatial Working Memory Impairments in Amyloid Precursor Protein Transgenic Mice (2005) Journal of Neuroscience 25:6755-6764.

Crabbe JC, Morris RG. (2004) Festina lente: late-night thoughts on high-throughput screening of mouse behavior.Nature Neuroscience 7:1175-9.

Daniel, A.C, Mesches, M.H., Alvarez, E., Bickford, P.C., and Browning, M.D. (2004) A Hippocampal NR2B Deficit Can Mimic Age-Related Changes in Long-Term Potentiation and Spatial Learning in the Fischer 344 Rat. Journal of Neuroscience, 22:3628-3637.

Livia de Hoz , Stephen J. Martin, Richard G. M. Morris (2004) Forgetting, Reminding, and Remembering: The Retrieval of Lost Spatial Memory. PLoS Biology 2:1233-1242.

Korzus, E., Rosenfeld, M.G. and Mayford, M (2004) CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation. Neuron 42:961-972.

Valentinuzzi VS, Menna-Barreto L, Xavier GF. (2004) Effect of circadian phase on performance of rats in the Morris water maze task.J Biol Rhythms.19:312-24.

Miller S, Yasuda M, Coats JK, Jones Y, Martone ME, Mayford M. (2002) Disruption of dendritic translation of CaMKIIalpha impairs stabilization of synaptic plasticity and memory consolidation. Neuron 36:507-19.

Daniel A. Clayton, Michael H. Mesches, Enriquez Alvarez, Paula C. Bickford, and Michael D. Browning (2002) A Hippocampal NR2B Deficit Can Mimic Age-Related Changes in Long-Term Potentiation and Spatial Learning in the Fischer 344 Rat. Journal of Neuroscience 22:3628-3637.

LimeLight

Daniel J. Abramsa, Lijun Zhenga, Kevin S. Chooa, Jun J. Yangb, Wei Weid, Thomas J. Anchordoquyb, Nasser H. Zawiad and Karen E. Stevens (2008) An initial animal proof-of-concept study for central administration of clozapine to schizophrenia patients. Schizophrenia Research In Press.

B. C. McKinney, J. S. Schneider, G. L. Schafer, J. L. Lowing, S. Mohan, M. X. Zhao, M. Y. Heng, R. L. Albin, A. F. Seasholtz, H. Akil, G. G. Murphy (2007)
Decreased locomotor activity in mice expressing tTA under control of the CaMKIIα promoter. Genes, Brains and Behavior [Epub].

Maggie Lai, Karen Horsburgh, Sung-Eun Bae, Roderick N. Carter, Dirk J. Stenvers, Jill H. Fowler, Joyce L. Yau, Celso E. Gomez-Sanchez, Megan C. Holmes, Christopher J. Kenyon, Jonathan R. Seckl, Malcolm R. Macleod (2007) Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia European Journal of Neuroscience 25:1832–1842.

Heidi G. Sutherland, Kathryn Newton, David G. Brownstein, Megan C. Holmes, Clémence Kress, Colin A. Semple, and Wendy A. Bickmore (2006) Disruption of Ledgf/Psip1 Results in Perinatal Mortality and Homeotic Skeletal Transformations. Molecular and Cellular Biology, 26:7201-7210.

Megan C. Holmes, Christian T. Abrahamsen, Karen L. French, Janice M. Paterson, John J. Mullins, and Jonathan R. Seckl (2006) The Mother or the Fetus? 11-Hydroxysteroid Dehydrogenase Type 2 Null Mice Provide Evidence for Direct Fetal Programming of Behavior by Endogenous Glucocorticoids. Journal of Neuroscience, 26:3840-3844.

Rong Chen, Michael R. Tilley, Hua Wei, Fuwen Zhou, Fu-Ming Zhou, San Ching, Ning Quan, Robert L. Stephens, Erik R. Hill, Timothy Nottoli, Dawn D. Han, and Howard H. Gu (2006) Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter.PNAS 103:9333-9338.

Michael T. Rogan, Kam Sam Leon, David L. Perez, and Eric R. Kandel (2005) Distinct Neural Signatures for Safety and Danger in the Amygdala and Striatum of the Mouse. Neuron 46:1–12.

ClockLab

Sofia I. H. Godinho, Elizabeth S. Maywood, Linda Shaw, Valter Tucci, Alun R. Barnard, Luca Busino, Michele Pagano, Rachel Kendall, Mohamed M. Quwailid, M. Rosario Romero, John O'Neill, Johanna E. Chesham, Debra Brooker, Zuzanna Lalanne, Michael H. Hastings, Patrick M. Nolan. (2007) The After Hours Mutant Reveals a Role for FBXL3 in Determining Mammalian Circadian Period. Science 316: 900-904.

Quan Yuan, William J. Joiner and Amita Sehgal (2006) A Sleep-Promoting Role for the Drosophila Serotonin Receptor. Current Biology 16:1051-1062.

Andrea L Meredith, Steven W Wiler, Brooke H Miller, Joseph S Takahashi, Anthony A Fodor, Norman F Ruby & Richard W Aldrich (2006) BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output. Nature Neuroscience 9:1041-1049.

Maureen K. Bunger, Lisa D. Wilsbacher, Susan M. Moran, Cynthia Clendenin, Laurel A. Radcliffe, John B. Hogenesch, M. Celeste Simon, Joseph S. Takahashi and Christopher A. Bradfield (2006) Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals. Cell, 103:1009-1017.

J. DeBruyne, E. Noton, C. Lambert, E. Maywood, D. Weaver, S. Reppert (2006) A Clock Shock: Mouse CLOCK Is Not Required for Circadian Oscillator Function. Neuron, 50:465-477.

Michael N. Nitabach, Ying Wu, Vasu Sheeba, William C. Lemon, John Strumbos, Paul K. Zelensky, Benjamin H. White and Todd C. Holmes (2006) Electrical Hyperexcitation of Lateral Ventral Pacemaker Neurons Desynchronizes Downstream Circadian Oscillators in the Fly Circadian Circuit and Induces Multiple Behavioral Periods. Journal of Neuroscience 26:479-489.

Susan E. Doyle, Ana Maria Castrucci, Maureen McCall, Ignacio Provencio, and Michael Menaker (2006) Nonvisual light responses in the Rpe65 knockout mouse: Rod loss restores sensitivity to the melanopsin system. PNAS 103:10432-10437.

Xiaodong Li, Jenifer Gilbert and Fred C. Davis (2005) Disruption of masking by hypothalamic lesions in Syrian hamsters Journal of Comparative Physiology 191:23-30.

A. Jennifer Morton, Nigel I. Wood, Michael H. Hastings, Carrie Hurelbrink, Roger A. Barker, and Elizabeth S. Maywood (2005) Disintegration of the Sleep-Wake Cycle and Circadian Timing in Huntington's Disease. Journal of Neuroscience 25:157-163.

Sara J Aton, Christopher S Colwell, Anthony J Harmar, James Waschek& Erik D Herzog (2005) Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons. Nature Neuroscience 8:476 - 483.

Aton, S. J., G. D. Block, H. Tei, S. Yamazaki and E. D. Herzog (2004). "Plasticity of circadian behavior and the suprachiasmatic nucleus following exposure to non-24-hour light cycles." J Biol Rhythms 19(3): 198-207.

Granados-Fuentes, D., L. M. Prolo, U. Abraham and E. D. Herzog (2004). "The suprachiasmatic nucleus entrains, but does not sustain, circadian rhythmicity in the olfactory bulb." Journal of Neuroscience 24(3): 615-9.

Granados-Fuentes, D., M. T. Saxena, L. M. Prolo, S. J. Aton and E. D. Herzog (2004). "Olfactory bulb neurons express functional, entrainable circadian rhythms." European Journal of Neuroscience 19(4): 898-906.

Han SL, Nelms, JL, Nguyen, M, Silver, R & Lehman, MN (2003) The eye is necessary for a circadian rhythm in the suprachiasmatic nucleus. Nature Neuroscience 6:111-112.

Lin, J. M., V. L. Kilman, K. Keegan, B. Paddock, M. Emery-Le, M. Rosbash and R. Allada (2002). "A role for casein kinase 2alpha in the Drosophila circadian clock." Nature 420(6917): 816-20.

Ruby, N. F., T. J. Brennan, X. Xie, V. Cao, P. Franken, H. C. Heller and B. F. O'Hara (2002). "Role of melanopsin in circadian responses to light." Science 298(5601): 2211-3.

Castrucci, AM, Rollag,, MD, DeGrip, WJ, Hogenesch, JD, Provencio, I & Kay, SA (2002) Melanopsin (Opn4) Requirement for Normal Light-Induced Circadian Phase Shifting. Science 298:2213-2215.

Daniel Gau, Thomas Lemberger, Charlotte von Gall, Oliver Kretz, Nguyet Le Minh, Peter Gass, Wolfgang Schmid, Ueli Schibler, Horst W. Korf, and Günther Schütz.(2002). Phosphorylation of CREB Ser142 Regulates Light-Induced Phase Shifts of the Circadian Clock. Neuron 34: 245-253.

Harmar AJ, Marston HM, Shen S, Spratt C, West KM, Sheward WJ, Morrison CF, Dorin JR, Piggins HD, Reubi JC, Kelly JS, Maywood ES, Hastings MH.(2002). The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei. Cell 109:497-508.

Williams, J. A., H. S. Su, A. Bernards, J. Field and A. Sehgal (2001). "A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK." Science 293(5538): 2251-6.Panda, S, Sato. TK,Shen S, Spratt C, Sheward WJ, Kallo I, West K, Morrison CF, Coen CW, Marston HM, Harmar AJ.(2000). Overexpression of the human VPAC2 receptor in the suprachiasmatic nucleus alters the circadian phenotype of mice. PNAS 97:11575-80.

Sharon S. Low-Zeddies and Joseph S. Takahashi (2001). Chimera Analysis of the Clock Mutation in Mice Shows that Complex Cellular Integration Determines Circadian Behavior. Cell 105: 25-42.

Maureen K. Bunger, Lisa D. Wilsbacher, Susan M. Moran, Cynthia Clendenin, Laurel A. Radcliffe, John B. Hogenesch, M. Celeste Simon, Joseph S. Takahashi, and Christopher A. Bradfield (2000) Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals. Cell 103: 1009.

LumiCycle

Wen-Ning Zhao, Nikolay Malinin, Fu-Chia Yang,, David Staknis, Nicholas Gekakis, Bert Maier, Silke Reischl, Achim Kramer & Charles J. Weitz (2007) CIPC is a mammalian circadian clock protein without invertebrate homologues. Nature Cell Biology 9:268 - 275.

Natsuko Inagaki, Sato Honma, Daisuke Ono, Yusuke Tanahashi, and Ken-ichi Honma (2007) Separate oscillating cell groups in mouse suprachiasmatic nucleus couple photoperiodically to the onset and end of daily activity. PNAS 104:7664-7669.

Mariko Izumo, Takashi R. Sato, Martin Straume, Carl Hirschie Johnson (2006) Quantitative Analyses of Circadian Gene Expression in Mammalian Cell Cultures. PLoS Computation Biology, 2:1248-1261.

Guo-Xiang Ruan, Dao-Qi Zhang, Tongrong Zhou, Shin Yamazaki, and Douglas G. McMahon (2006) Circadian organization of the mammalian retina. PNAS 103:9703-9708.

Katja Vanselow, Jens T. Vanselow, Pål O. Westermark, Silke Reischl, Bert Maier, Thomas Korte, Andreas Herrmann, Hanspeter Herzel2, Andreas Schlosser and Achim Kramer (2006) Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes and Development, 20:2660-2672.

Alec J. Davidson, Martin Straume, Gene D. Block, Michael Menaker (2006) Daily timed meals dissociate circadian rhythms in hepatoma and healthy host liver. International Journal of Cancer 118:1623-1627.

Martha Hotz Vitaterna, Caroline H. Ko, Anne-Marie Chang, Ethan D. Buhr, Ethan M. Fruechte, Andrew Schook, Marina P. Antoch, Fred W. Turek, and Joseph S. Takahashi (2006) The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase–response curve amplitude. PNAS 103:9327-9332.

Fukuhara C, Yamazaki S, Liang J. (2005) Pineal circadian clocks gate arylalkylamine N-acetyltransferase gene expression in the mouse pineal gland. Journal of Neurochemistry 93:156-62

Chiaki Fukuhara, Shin Yamazaki and Jian Liang (2005) Pineal circadian clocks gate arylalkylamine N-acetyltransferase gene expression in the mouse pineal gland. Journal of Neurochemistry 93:1471-4159.

Yoo SH, Ko CH, Lowrey PL, Buhr ED, Song EJ, Chang S, Yoo OJ, Yamazaki S, Lee C, Takahashi JS. (2005) A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo. PNAS 102:2608-13.

David K. Welsh, Seung-Hee Yoo, Andrew C. Liu, Joseph S. Takahashi, and Steve A. Kay. (2004) Bioluminescence Imaging of Individual Fibroblasts Reveals Persistent, Independently Phased Circadian Rhythms of Clock Gene Expression. Current Biology 14:2289-95.

Mariko Izumo, Carl Hirschie Johnson and Shin Yamazaki (2003). Circadian gene expression in mammalian fibroblasts revealed by real-time luminescence reporting: Temperature compensation and damping. PNAS 100:16089-16094.